Main competences of Research Institute of Viticulture and Enology-PTE (RIVE) are: (i) germplasm preservation in a gene bank over 1600 accessions, (ii) clonal selection of 16, mainly Hungarian autochton cultivars, (iii) plant physiological measurements for selecting cultivars with better adaptation to climate change, (iv) germplasm evaluation for new resistance sources against several pathogens. A Vitis vinifera powdery mildew resistance source with monogenic resistance was introduced into breeding. Three monogenic powdery mildew resistance genes and three monogenic downy mildew resistance genes are currently being used in breeding programmes for high quality cultivars with durable multiple resistances.